OI Ljubljana

Head of the Department of Cytopathology
Prof. Veronika Kloboves Prevodnik, MD, PhD
Tel: +386 1 5879 703
Fax: +386 1 5879 802
e-mail: vkloboves@onko-i.si

Fields of work

The department performs cytopathological diagnostics for IO and other Slovenian health institutions. The outpatient clinic performs fine needle aspiration biopsies (FNAB) of palpable lumps and masses, skin scrapings, collection of nipple discharges, and smears. The laboratory processes and examines various cytological samples of patients suspected to have benign or malignant tumours. Immunocytochemical and flow-cytometric immunophenotyping techniques are used in difficult cases to obtain a more reliable cytopathological diagnosis. The laboratory also performs examinations of peripheral blood and bone marrow samples, as well as high-risk human papillomavirus (HPV) testing for women with low grade cytology abnormalities in PAP smear.

Key professional and technological achievements

In the last decade, the department has made significant progress, especially in the fields of cervical cancer diagnostics, immunocytochemistry and flow cytometry diagnostics of lymphoma and leukaemia. In the framework of the ZORA national organised screening programme, they started to perform triage tests for high-risk human papillomaviruses (HPV) with Hybrid Capture 2 Assay in 2010. Hybrid Capture 2 in 2010. With the development of new antibodies, immunocytochemistry became an important additional method for classifying malignant tumours and diagnosing cancer of unknown primary. In 2013, they joined the iBFM international consortium and started to provide flow cytometry diagnostics of minimal disease residues in children with acute lymphoblastic leukaemia for the whole Slovenia. Two years later, they received the first international certificate for performing these diagnostics. In 2015, the implementation of the 10-colour flow cytometer enabled more reliable diagnoses of lymphoma and leukaemia, especially in samples with few cells.



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