OI Ljubljana
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Pulsed Electric Fields Applications in Biology and Medicine

Principal investigator at the Institute of Oncology Ljubljana: Gregor Serša PhD

An Associated European Laboratory (LEA) is a “laboratory without walls” devoid of legal personality or capacity which brings together two or more laboratories or parts of laboratories from CNRS – and, possibly, from an higher education organization and one or more research organizations or universities from other European countries.

The main aim of the LEA EBAM is to use an interdisciplinary approach, integrating biology, chemistry, physics, biophysics, mathematics, computational modelling and engineering, through the expertise of its members in order to:

  1. enhance our understanding on the mechanisms of classical electropermeabilization and of the new nanopermeabilization (electropermea-bilization using nanosecond electric pulses), as well as on the mechanisms of transmembrane transport of molecules into electroporated cells and tissues on a microscopic and macroscopic scale;

  1. contribute to a better and safer implementation of the electropermeabilization-based applications, and to the development of new applications;

  1. develop new devices and new equipment for the nanopermeabilisation at cell and tissue levels;

  1. develop new approaches like treatment planning in existing applications, such as antitumor electrochemotherapy and in vivo gene transfer for therapeutic purposes;

  1. disseminate the knowledge and the applications in the scientific community and in the society, through publications, a one-week course (already implemented) co-directed by the LEA directors, internal and external training, and through other means that the LEA will develop and/or will apply for (to the EC programs for example).

 

Partners participating in the project possess complementary knowledge and skills, which only if brought together will allow for successful accomplishments of the above objectives.

 

 

© 2019 - Institute of Oncology Ljubljana
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