OI Ljubljana

Head of the Department of Cytopathology
Prof. Veronika Kloboves Prevodnik, MD, PhD
Tel: +386 1 5879 709
Fax: +386 1 5879 802
e-mail: cito.administracija@onko-i.si

Fields of work

The department performs cytopathological diagnostics for the Institute of Oncology (OI) and other Slovenian health institutions. The material is obtained by cytopathologists in the outpatient clinic, as well as by radiologists and clinicians at OI and other Slovenian health institutions. Cytological samples processed and examined in the laboratory are fine needle aspiration biopsies, skin scrapings, nipple discharge smears, body cavity fluids, peripheral blood, bone marrow aspirates and cervical smears. If needed, additional techniques such as immunocytochemistry and flow cytometry can be implemented on cytological samples. Also, testing for high-risk human papilloma virus (HPV) is available for women with low-grade abnormalities in cervical smear.

Key professional and technological achievements

The laboratory is involved in the Slovenian organized national screening programme for early detection of cervical cancer (ZORA) and since 2010 has been one of the two institutions in Slovenia performing triage tests for high-risk HPV.
Immunocytochemistry has been part of the diagnostic workup since 1986 and each year new antibodies are tested and added to our routine work. This not only improves diagnostics of neoplastic and non-neoplastic processes but also enables the exact classification and provides information on predictive and prognostic markers of malignant neoplasms.
Flow cytometry has been performed on lymphoid lesions since 1989. The implementation of 10-colour flow cytometer in 2015 enabled more reliable diagnostics of lymphoma and leukaemia, especially on low-cellularity samples. In 2013 the laboratory joined the BFM international consortium and has been certified for the examination of bone marrow aspirates of children with acute lymphoblastic leukaemia for minimal residual disease since 2015.



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