Representative publications

For the full publication list please follow the link: https://pubmed.ncbi.nlm.nih.gov/collections/54902766/?sort=pubdate

• Cvetkoska, A., Dermol-Černe, J., Miklavčič, D., Kranjc Brezar, S., Markelc, B., Serša, G., & Reberšek, M. (2022). Design, Development, and Testing of a Device for Gene Electrotransfer to Skin Cells In Vivo. Pharmaceutics, 14(9), 1826. doi: 10.3390/pharmaceutics14091826
• Bertino, G., Groselj, A., Campana, L. G., Kunte, C., Schepler, H., Gehl, J., Muir, T., Clover, J., Quaglino, P., Kis, E., Mascherini, M., Bisase, B., Pecorari, G., Bechara, F., Matteucci, P., Odili, J., Russano, F., Orlando, A., Pritchard-Jones, R., Moir, G., … Sersa, G. (2022). Electrochemotherapy for the treatment of cutaneous squamous cell carcinoma: The INSPECT experience (2008-2020). Frontiers in oncology, 12, 951662. doi: 10.3389/fonc.2022.951662
• Remic, T., Sersa, G., Levpuscek, K., Lampreht Tratar, U., Ursic Valentinuzzi, K., Cör, A., & Kamensek, U. (2022).Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response. Frontiers in immunology, 13, 974912. doi: 10.3389/fimmu.2022.974912
• Bosnjak, M., Znidar, K., Sales Conniff, A., Jesenko, T., Markelc, B., Semenova, N., Tur, J., Kohena, K., Kranjc Brezar, S., Heller, L., & Cemazar, M. (2022).In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 150, 113088. doi: 10.1016/j.biopha.2022.113088
• Trotovsek, B., Hadzialjevic, B., Cemazar, M., Sersa, G., & Djokic, M. (2022). Laparoscopic electrochemotherapy for the treatment of hepatocellular carcinoma: Technological advancement. Frontiers in oncology, 12, 996269. doi: 10.3389/fonc.2022.996269
• Groselj, A., Bosnjak, M., Jesenko, T., Cemazar, M., Markelc, B., Strojan, P., & Sersa, G. (2022). Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol. Radiology and oncology, 56(3), 398–408. doi: 10.2478/raon-2022-0021.

• Campana LG, Peric B, Mascherini M, Spina R, Kunte C, Kis E, Rozsa P, Quaglino P, Jones RP, Clover AJP, et al (2021) Combination of pembrolizumab with electrochemotherapy in cutaneous metastases from melanoma: A comparative retrospective study from the inspect and slovenian cancer registry. Cancers (Basel) 13 doi: 10.3390/cancers13174289
• Groselj A, Bosnjak M, Krzan M, Kosjek T, Bottyán K, Plesnik H, Jamsek C, Cemazar M, Kis E & Sersa G (2021) Bleomycin concentration in patients’ plasma and tumors after electrochemotherapy. A study from inspect group. Pharmaceutics 13 doi: 10.3390/pharmaceutics13091324
• Kos S, Bosnjak M, Jesenko T, Markelc B, Kamensek U, Znidar K, Matkovic U, Rencelj A, Sersa G, Hudej R, et al (2021) Non-clinical in vitro evaluation of antibiotic resistance gene-free plasmids encoding human or murine IL-12 intended for first-in-human clinical study. Pharmaceutics 13: 1739 doi: 10.3390/pharmaceutics13101739
• Sersa G, Ursic K, Cemazar M, Heller R, Bosnjak M & Campana LG (2021) Biological factors of the tumour response to electrochemotherapy: Review of the evidence and a research roadmap. Eur J Surg Oncol 47: 1836–1846 doi:10.1016/j.ejso.2021.03.229
• Sremački I, Kos Š, Bošnjak M, Jurov A, Serša G, Modic M, Leys C, Cvelbar U & Nikiforov A (2021) Plasma Damage Control: From Biomolecules to Cells and Skin. ACS Appl Mater Interfaces 13 doi: 10.1021/acsami.1c12232
• Ursic K, Kos S, Kamensek U, Cemazar M, Miceska S, Markelc B, Bucek S, Staresinic B, Kloboves Prevodnik V, Heller R, et al (2021) Potentiation of electrochemotherapy effectiveness by immunostimulation with IL-12 gene electrotransfer in mice is dependent on tumor immune status. J Control Release 332: 623–635 doi: 10.1016/j.jconrel.2021.03.009

• Dežman R, Čemažar M, Serša G, Seliškar A, Erjavec V, Trotovšek B, Gašljevič G, Bošnjak M, Lampreht Tratar U, Kos B, et al (2020) Safety and feasibility of electrochemotherapy of the pancreas in a porcine model. Pancreas 49: 1168–1173 doi: 10.1097/MPA.0000000000001642
• Jesenko T, Bosnjak M, Markelc B, Sersa G, Znidar K, Heller L & Cemazar M (2020) Radiation induced upregulation of DNA sensing pathways is cell-type dependent and can mediate the off-target effects. Cancers (Basel) 12: 1–23 doi: 10.3390/cancers12113365
• Kranjc Brezar S, Prevc A, Niksic Zakelj M, Brozic A, Cemazar M, Strojan P & Sersa G (2020) Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma. Sci Rep 10 doi: 10.1038/s41598-020-58502-9
• Milevoj N, Tozon N, Licen S, Lampreht Tratar U, Sersa G & Cemazar M (2020) Health-related quality of life in dogs treated with electrochemotherapy and/or interleukin-12 gene electrotransfer. Vet Med Sci 6: 290–298 doi: 10.1002/vms3.232

• Cemazar M & Sersa G (2019) Recent advances in electrochemotherapy. Bioelectricity 1: 204–213 doi: 10.1089/bioe.2019.0028
• Semenova N, Bosnjak M, Markelc B, Znidar K, Cemazar M & Heller L (2019) Multiple cytosolic DNA sensors bind plasmid DNA after transfection. Nucleic Acids Res 47: 10235–10246 doi: 10.1093/nar/gkz768
• Kos S, Lopes A, Preat V, Cemazar M, Tratar UL, Ucakar B, Vanvarenberg K, Sersa G & Vandermeulen G (2019) Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma. PLoS One 14 doi: 10.1371/journal.pone.0217762
• Campana LG, Edhemovic I, Soden D, Perrone AM, Scarpa M, Campanacci L, Cemazar M, Valpione S, Miklavčič D, Mocellin S, et al (2019) Electrochemotherapy – Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol 45: 92–102 doi:10.1016/j.ejso.2018.11.023
• Campana LG, Kis E, Bottyán K, Orlando A, de Terlizzi F, Mitsala G, Careri R, Curatolo P, Snoj M, Sersa G, et al (2019) Electrochemotherapy for advanced cutaneous angiosarcoma: A European register-based cohort study from the International Network for Sharing Practices of electrochemotherapy (InspECT). Int J Surg 72: 34–42 doi: 10.1016/j.ijsu.2019.10.013
• Todorovic V, Prevc A, Zakelj MN, Savarin M, Brozic A, Groselj B, Strojan P, Cemazar M & Sersa G (2019) Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines. Radiat Oncol 14 doi: 10.1186/s13014-019-1418-6

• C.C. Plaschke, G. Bertino, J.A. McCaul, J.J. Grau, R. de Bree, G. Sersa, et al., European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers, Eur. J. Cancer. 87 (2017) 172–181. doi:10.1016/j.ejca.2017.10.008.
• M. Kranjc, S. Kranjc, F. Bajd, G. Serša, I. Serša, D. Miklavčič, Predicting irreversible electroporation-induced tissue damage by means of magnetic resonance electrical impedance tomography., Sci. Rep. 7 (2017) 10323. doi:10.1038/s41598-017-10846-5.
• A. Mitrović, I. Sosič, Š. Kos, U.L. Tratar, B. Breznik, S. Kranjc, et al., Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo., Oncotarget. 8 (2017) 59136–59147. doi:10.18632/oncotarget.19296.
• S. Kos, K. Vanvarenberg, T. Dolinsek, M. Cemazar, J. Jelenc, V. Préat, et al.,Gene electrotransfer into skin using noninvasive multi-electrode array for vaccination and wound healing., Bioelectrochemistry. 114 (2017) 33–41. doi:10.1016/j.bioelechem.2016.12.002.

• Kos S, Blagus T, Cemazar M, Lampreht Tratar U, Stimac M, Prosen L, Dolinsek T, Kamensek U, Kranjc S, Steinstraesser L, Vandermeulen G, Préat V, Sersa G.Electrotransfer parameters as a tool for controlled and targeted gene expression in skin. Mol Ther Nucleic Acids, 2016; 30;5(8):e356. [PubMed: 27574782]
• Prevc A, Bedina Zavec A, Cemazar M, Kloboves-Prevodnik V, Stimac M, Todorovic V, Strojan P, Sersa G. Bystander Effect Induced by Electroporation is Possibly Mediated by Microvesicles and Dependent on Pulse Amplitude, Repetition Frequency and Cell Type. J Membr Biol. 2016; 1. October 2016, Volume 249, Issue 5, pp 703–711. [PubMed: 27371159]
• Cemazar M, Ambrozic Avgustin J, Pavlin D, Sersa G, Poli A, Krhac Levacic A, Tesic N, Lampreht Tratar U, Rak M, Tozon N.Efficacy and safety of electrochemotherapy combined with peritumoral IL-12 gene electrotransfer of canine mast cell tumours. Vet Comp Oncol. 2016; 3. [Epub ahead of print] [PubMed: 26840222]
• Stimac M, Kamensek U, Cemazar M, Kranjc S, Coer A, Sersa G. Tumor radiosensitization by gene therapy against endoglin. Cancer Gene Ther. 2016;23(7):214-20. [PubMed: 27199221]
• Kamensek U, Rols MP, Cemazar M, Golzio M. Visualization of Nonspecific Antitumor Effectiveness and Vascular Effects of Gene Electro-Transfer to Tumors. Curr Gene Ther. 2016;16(2):90-7. [PubMed: 27029945]
• Lambricht L, Lopes A, Kos S, Sersa G, Préat V, Vandermeulen G.Clinical potential of electroporation for gene therapy and DNA vaccine delivery. Expert Opin Drug Deliv. 2016;13(2):295-310. [PubMed: 26578324]

• Dolinsek T., Markelc B., Bosnjak M., Blagus T., Prosen L., Kranjc S., Stimac M., Lampreht U., Sersa G., Cemazar M. Endoglin Silencing has Significant Antitumor Effect on Murine Mammary Adenocarcinoma Mediated by Vascular Targeted Effect.Current Gene Therapy, 2015;15(3):228-4. [PubMed: 25619888]
• Sersa G, Teissie J, Cemazar M, Signori E, Kamensek U, Marshall G, Miklavcic D. Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer. Cancer Immunol Immunother. 2015;64(10):1315-27. [PubMed: 26067277]
• Tesic N, Kamensek U, Sersa G, Kranjc S, Stimac M, Lampreht U, Preat V, Vandermeulen G, Butinar M, Turk B, Cemazar M. Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma.Mol Ther Nucleic Acids. 2015;4:e239. [PubMed: 25942402]
• Cemazar M, Todorovic V, Scancar J, Lampreht U, Stimac M, Kamensek U, Kranjc S, Coer A,Sersa G. Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.Radiol Oncol. 2015;49(1):32-40. [PubMed: 25810699]
  Mali B, Gorjup V, Edhemovic I, Brecelj E, Cemazar M, Sersa G, Strazisar B, Miklavcic D, Jarm T. Electrochemotherapy of colorectal liver metastases-an observational study of its effects on the electrocardiogram. Biomed Eng Online. 2015;14 Suppl 3:S5. [PubMed: 26356120]

• Miklavcic D., Mali B., Kos B., Heller R., Sersa G. Electrochemotherapy: from the drawing board into medical practice. Biomed Eng Online, 2014; 13: 1-29. [PubMed: 24621079]
• Blagus T., Zager V., Cemazar M., Kotnik T., Sersa G., Kamensek U., Nunic J., Filipic M. A cell-based biosensor system HepG2CDKN1A-DsRed for rapid and simple detection of genotoxic agents. Biosensors & Bioelectronics, 2014; 61: 102-111. [PubMed: 24861570]
• Yarmush M.L., Golberg A., Sersa G., Kotnik T., Miklavcic D. Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges. Annu Rev Biomed Eng, 2014; 16: 295-320. [PubMed: 24905876]
• Edhemovic I., Brecelj E., Gasljevic G., Marolt Music M., Gorjup V., Mali B., Jarm T., Kos B., Pavliha D., Grcar Kuzmanov B., Cemazar M., Snoj M., Miklavcic D., Gadzijev E. M., Sersa G. Intraoperative Electrochemotherapy of Colorectal Liver Metastases. J Surg Oncol, 2014; 110: 320-327. [PubMed: 24782355]
• Prosen L., Markelc B., Dolinsek T., Music M., Cemazar M., Sersa G. Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma. Mol Imaging Biol, 2014; 3: 1-14. [PubMed: 25350580]

• Sedlar A., Kranjc S., Dolinsek T., Cemazar M., Coer A., Sersa G. Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma. BMC Cancer, 2013; 13 (38): 1-11. [PubMed: 23360213]
• Todorovic V., Sersa G., Cemazar M. Gene electrotransfer of siRNAs against CD146 inhibits migration and invasion of human malignant melanoma cells SK-MEL28. Cancer Gene Ther, 2013; 20(3): 208-10. [PubMed: 23370332]
• Dolinsek T., Markelc B., Sersa G., Coer A., Stimac M., Lavrencak J., Brozic A., Kranjc S., Cemazar M. Multiple Delivery of siRNA against Endoglin into Murine Mammary Adenocarcinoma Prevents Angiogenesis and Delays Tumor Growth. PLOS ONE, 2013; 8(3): e58723. [PubMed: 23593103]
• Tesic N., Cemazar M. In vitro targeted gene electrotransfer to endothelialcells withplasmid DNA containing human endothelin-1 promoter. J Membr Biol, 2013; 246(10): 783-91. [PubMed: 23652810]
• Bosnjak M., Prosen L., Dolinsek T., Blagus T., Markelc B., Cemazar M., Bouquet C., Sersa G. Biological properties of melanoma and endothelial cells afterplasmid AMEP gene electrotransfer depend on integrin quantity on cells. J Membr Biol, 2013; 246(11): 803-19. [PubMed: 23649038]
• Kamensek U., Sersa G., Cemazar M. Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model. Mol Cancer  , 2013; 12(136): 1-12. [PubMed: 24219565]
• Spanggaard I., Snoj M., Cavalcanti A., Bouquet C., Sersa G., Robert C., Cemazar M., Dam E., Vasseur B., Attali P., Mir L.M., Gehl J. Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study. Human Gene Ther Clin Developme, 2013; 24: 99-107.[PubMed: 23980876]
• Prosen L., Prijic S., Music M., Lavrencak J., Cemazar M., Sersa G. Magnetofection: a reproducible method for gene delivery to melanoma cells. Biomed Res Int, 2013; 2013: 209452. [PubMed: 23862136]
• Markelc B., Sersa G., Cemazar M. Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels. PLOS ONE, 2013; 8(3): e59557. [PubMed: 23555705]
• Blagus T., Markelc B., Cemazar M., Kosjek T., Preat V., Miklavcic D., Sersa G. In vivo real-time monitoring system of electroporation mediated control of transdermal and topical drug delivery. J Control Release, 2013; 172(3): 862-871. [PubMed: 24113487]
• Todorovic V., Kamensek U., Sersa G., Cemazar M. Changing electrode orientation, but not pulse polarity, increases the efficacy of gene electrotransfer to tumors in vivo. Bioelectrochemistry, 2013; BIOJEC-06714: 1-9.

• Prijic S., Prosen L., Cemazar M., Scancar J., Romih R., Lavrencak J., Bregar V. B., Coer A., Krzan M., Znidarsic A., Sersa G. Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma.Biomaterials, 2012; 33: 4379-4391. [PubMed: 22429983]
• Markelc B., Bellard E., Sersa G., Pelofy S., Teissie J., Coer A., Golzio M., Cemazar M. In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice. J Membr Biol, 2012; 245(9): 545-54. [PubMed: 22644389]
• Miklavcic D., Sersa G., Brecelj E., Gehl J., Soden D., Bianchi G., Ruggieri P., Rossi C.R., Campana L.G., Jarm T. Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors.Med Biol Eng Comp, 2012; 50: 1213-1225. [PubMed: 23179413]

• Kamensek U., Sersa G., Mesojednik S., Tevz G., Kranjc S., Cemazar M. Irradiation, cisplatin, and 5-Azacytidine upregulate cytomegalovirus promoter in tumors and muscles: implementation of non-invasive fluorescence imaging.Mol Imaging Biol, 2011. 13: 43-52. [PubMed: 20396957]
• Sersa G., Gehl J., Garbay J.R., Soden D., O`Sullivan G.C., Matthiessen L.V., Snoj M., Mir L.M. Electrochemotherapy of Small Tumors; The Experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) Group. Clinical Aspects of Electropor, 2011; 8: 93-102.
• Sersa G., Cemazar M. Vascular-Disrupting Action of Electrochemotherapy: Mode of Action and Therapeutic Implications.Clinical Aspects of Electropor, 2011; 7: 83-91.

• Cemazar M., Jarm T., Sersa G. Cancer electrogene therapy with interleukin-12. Curr Gene Ther, 2010; 10: 300-311. [PubMed: 20560875]
• Jarm T., Cemazar M., Miklavcic D., Sersa G. Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther, 2010; 10(5): 729-746. [PubMed: 20470005]
• Miklavcic D., Snoj M., Zupanic A., Kos B., Cemazar M., Kropivnik M., Bracko M., Pecnik T., Gadzijev E. M., Sersa G. Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy.Biomed Eng Online, 2010; 9: 10. [PubMed: 20178589]

• Kranjc S., Tevz G., Kamensek U., Mesojednik S., Cemazar M., Sersa G. Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model.Radiat Res, 2009; 172: 677-685. [PubMed: 19929414]
• Tevz G., Kranjc S., Cemazar M., Kamensek U., Coer A., Krzan M., Mesojednik S., Pavlin D., Sersa G. Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.J Gene Med, 2009; 11: 1125-1137. [PubMed: 19777440]

• Sersa G., Miklavic D., Cemazar M, Rudolf Z., Pucihar G., Snoj M. Electrochemotherapy in treatment of tumours.Eur J Surg Oncol, 2008; 34(2): 232-240. [PubMed: 17614247]
• Sersa G., Jarm T., Kotnik T., Coer A., Podkrajšek M., Sentjurc M., Miklavcic D., Kadivec M., Kranjc S., Semrov D., Cemazar M. Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma.Brit J Cancer, 2008; 98(2): 388-398. [PubMed: 18182988]
• Sersa G., Miklavcic D. Electrochemotherapy of tumours.J Vis Exp, 2008; 22: 1038. [PubMed: 19370177]
• Cemazar M., Tamzali Y., Sersa G., Tozon N., Mir L.M., Miklavcic D., Lowe R., Teissie J. Electrochemotherapy in veterinary oncology.J Vet Intern Med, 2008; 22(49): 826-831. [PubMed: 18537879]

• Cemazar M., Sersa G. Electrotransfer of therapeutic molecules into tissues. Curr Opin Mol Ther, 2007; 9(6): 554-562. [PubMed: 18041666]