Effect of perioperative intravenous infusion of lidocaine or high-dose dexamethasone on the immune response in patients undergoing surgery for colon cancer – the PILDI study

The study investigates whether the use of lidocaine during surgery can improve recovery in patients after surgical treatment for colon cancer.

After surgery for colon cancer, patients often require pain medicines, such as opioids, which may cause side effects including nausea, constipation and slower recovery. In this study, we investigate whether lidocaine can reduce the need for these medicines and contribute to faster recovery.

Purpose of the study

To determine whether the use of lidocaine during surgery affects postoperative pain, the use of pain medicines and the return of normal bowel function. Pain intensity and the inflammatory marker IL-8 will also be monitored during the first two days after surgery.

Study procedure

If the patient decides to participate, they will receive all necessary information and sign an informed consent form before surgery.

Patients will be randomly assigned to one of two groups:

one group will receive lidocaine during surgery,

the other group will receive placebo (saline solution).

Surgery and further treatment will follow established guidelines. After the procedure, the following will be monitored:

• pain,
• use of pain medicines (opioid analgesics),
• time to first bowel movement and passing gas,
• possible complications.

Patients will also be followed after discharge from hospital.

Who can take part?

Patients referred for surgery due to colon cancer.

How to apply?

The patient will be informed about the possibility of participation by a physician before surgery. Participation is voluntary and may be withdrawn at any time without affecting further treatment.

The study has been approved by the competent ethics committee.